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1gm6

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{{STRUCTURE_1gm6| PDB=1gm6 | SCENE= }}
{{STRUCTURE_1gm6| PDB=1gm6 | SCENE= }}
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'''3-D STRUCTURE OF A SALIVARY LIPOCALIN FROM BOAR'''
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===3-D STRUCTURE OF A SALIVARY LIPOCALIN FROM BOAR===
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==Overview==
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The X-ray structure of variant A of authentic boar salivary lipocalin (SAL), a pheromone-binding protein specifically expressed in the submaxillary glands of the boar, has been solved and refined at 2.1 A resolution. The structure displays a classical lipocalin fold with a nine-stranded sandwiched beta barrel and an alpha helix. A putative glycosylation site, at position 53, has been found to carry a GlcNAc sugar residue. In contrast with what was expected on the basis of mass spectroscopy reports, the internal cavity was found to be devoid of bound pheromonal compound (androstenone or androstenol). Instead, a small electron density volume could be satisfied by a glycerol molecule, a component of the cryoprotecting liquor. The internal cavity was revealed to be very small for steroid compound accommodation. Therefore, docking and molecular dynamics experiments were performed with both pheromonal compounds. These simulations clearly demonstrate a volume increase of the cavity upon steroid binding and the adaptation of the amino-acid side chains to the steroid molecules. This explains the higher affinity of SAL for both steroid molecules compared to other smaller molecules, although no specific interaction is established with either compound.
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(as it appears on PubMed at http://www.pubmed.gov), where 12027882 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12027882}}
==About this Structure==
==About this Structure==
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[[Category: Odorant binding protein]]
[[Category: Odorant binding protein]]
[[Category: Salivary lipocalin]]
[[Category: Salivary lipocalin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:44:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:30:31 2008''

Revision as of 02:30, 1 July 2008

Image:1gm6.png

Template:STRUCTURE 1gm6

3-D STRUCTURE OF A SALIVARY LIPOCALIN FROM BOAR

Template:ABSTRACT PUBMED 12027882

About this Structure

1GM6 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Boar salivary lipocalin. Three-dimensional X-ray structure and androsterol/androstenone docking simulations., Spinelli S, Vincent F, Pelosi P, Tegoni M, Cambillau C, Eur J Biochem. 2002 May;269(10):2449-56. PMID:12027882

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