This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1go6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1go6.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1go6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1go6| PDB=1go6 | SCENE= }}
{{STRUCTURE_1go6| PDB=1go6 | SCENE= }}
-
'''BALHIMYCIN IN COMPLEX WITH LYS-D-ALA-D-ALA'''
+
===BALHIMYCIN IN COMPLEX WITH LYS-D-ALA-D-ALA===
-
==Overview==
+
<!--
-
The vancomycin-related antibiotics balhimycin and degluco-balhimycin have been crystallized in complexes with di-, tri- and pentapeptides that emulate bacterial cell-wall precursors, and four structures determined at atomic resolution (&lt;1 A). In addition to the features expected from previous structural and spectroscopic studies, two new motifs were observed that may prove important in the design of antibiotics modified to overcome bacterial resistance. A changed binding mode was found in two dipeptide complexes, and a new type of face-to-face oligomerization (in addition to the well-established back-to-back dimerization) was seen when the model peptide reaches a critical fraction of the size of the cell-wall precursor pentapeptide. The extensive interactions involving both antibiotic and peptide molecules in this interface should appreciably enhance the kinetic and thermodynamic stability of the complexes. In the pentapeptide complex, the relative positions of the peptides are close to those required for d-Ala elimination, so this structure may provide a realistic model for the prevention of the enzyme-catalyzed cell-wall crosslinking by antibiotic binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12054818}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12054818 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12054818}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Peptide complex]]
[[Category: Peptide complex]]
[[Category: Vancomycin]]
[[Category: Vancomycin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:48:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:35:35 2008''

Revision as of 02:35, 1 July 2008

Image:1go6.png

Template:STRUCTURE 1go6

BALHIMYCIN IN COMPLEX WITH LYS-D-ALA-D-ALA

Template:ABSTRACT PUBMED 12054818

About this Structure

1GO6 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structures of glycopeptide antibiotics with peptides that model bacterial cell-wall precursors., Lehmann C, Bunkoczi G, Vertesy L, Sheldrick GM, J Mol Biol. 2002 May 3;318(3):723-32. PMID:12054818

Page seeded by OCA on Tue Jul 1 05:35:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1go6"
Personal tools