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1gp0

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{{STRUCTURE_1gp0| PDB=1gp0 | SCENE= }}
{{STRUCTURE_1gp0| PDB=1gp0 | SCENE= }}
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'''HUMAN IGF2R DOMAIN 11'''
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===HUMAN IGF2R DOMAIN 11===
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==Overview==
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Insulin-like growth factor II receptor (IGF2R) is a multifunctional cell surface receptor implicated in tumour suppression. Its growth inhibitory activity has been associated with an ability to bind IGF-II. IGF2R contains 15 homologous extracellular domains, with domain 11 primarily responsible for IGF-II binding. We report a 1.4 A resolution crystal structure of domain 11, solved using the anomalous scattering signal of sulfur. The structure consists of two crossed beta-sheets forming a flattened beta-barrel. Structural analysis identifies the putative IGF-II binding site at one end of the beta-barrel whilst crystal lattice contacts suggest a model for the full-length IGF2R extracellular region. The structure factors and coordinates of IGF2R domain 11 have been deposited in the Protein Data Bank (accession codes 1GP0 and 1GP3).
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(as it appears on PubMed at http://www.pubmed.gov), where 11867533 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11867533}}
==About this Structure==
==About this Structure==
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[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Transport]]
[[Category: Transport]]
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Revision as of 02:37, 1 July 2008

Image:1gp0.png

Template:STRUCTURE 1gp0

HUMAN IGF2R DOMAIN 11

Template:ABSTRACT PUBMED 11867533

About this Structure

1GP0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur., Brown J, Esnouf RM, Jones MA, Linnell J, Harlos K, Hassan AB, Jones EY, EMBO J. 2002 Mar 1;21(5):1054-62. PMID:11867533

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