1gv7

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{{STRUCTURE_1gv7| PDB=1gv7 | SCENE= }}
{{STRUCTURE_1gv7| PDB=1gv7 | SCENE= }}
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'''ARH-I, AN ANGIOGENIN/RNASE A CHIMERA'''
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===ARH-I, AN ANGIOGENIN/RNASE A CHIMERA===
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==Overview==
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Angiogenin and ribonuclease A share 33% sequence identity but have distinct functions. Angiogenin is a potent inducer of angiogenesis that is only weakly ribonucleolytic, whereas ribonuclease A is a robust ribonuclease that is not angiogenic. A chimera ("ARH-I"), in which angiogenin residues 58-70 are replaced with residues 59-73 of ribonuclease A, has intermediate ribonucleolytic potency and no angiogenic activity. Here we report a crystal structure of ARH-I that reveals the molecular basis for these characteristics. The ribonuclease A-derived (guest) segment adopts a structure largely similar to that in ribonuclease A, and successfully converts this region from a cell-binding site to a purine-binding site. At the same time, its presence causes complex changes in the angiogenin-derived (host) portion that account for much of the increased ribonuclease activity of ARH-I. Guest-host interactions of this type probably occur more generally in protein chimeras, emphasizing the importance of direct structural information for understanding the functional behavior of such molecules.
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{{ABSTRACT_PUBMED_12173935}}
==About this Structure==
==About this Structure==
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[[Category: Hybrid]]
[[Category: Hybrid]]
[[Category: Pancreatic ribonuclease]]
[[Category: Pancreatic ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:03:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:08:18 2008''

Revision as of 03:08, 1 July 2008

Image:1gv7.png

Template:STRUCTURE 1gv7

ARH-I, AN ANGIOGENIN/RNASE A CHIMERA

Template:ABSTRACT PUBMED 12173935

About this Structure

1GV7 is a Single protein structure of sequence from Homo sapiens, bos taurus. Full crystallographic information is available from OCA.

Reference

Guest-host crosstalk in an angiogenin-RNase A chimeric protein., Holloway DE, Shapiro R, Hares MC, Leonidas DD, Acharya KR, Biochemistry. 2002 Aug 20;41(33):10482-9. PMID:12173935

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