1gve

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1gve.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1gve.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1gve| PDB=1gve | SCENE= }}
{{STRUCTURE_1gve| PDB=1gve | SCENE= }}
-
'''AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER'''
+
===AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER===
-
==Overview==
+
<!--
-
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has been solved to 1.38-A resolution. Although it shares a similar alpha/beta-barrel structure with other members of the aldo-keto reductase superfamily, AKR7A1 is the first dimeric member to be crystallized. The crystal structure also reveals details of the ternary complex as one subunit of the dimer contains NADP(+) and the inhibitor citrate. Although the underlying catalytic mechanism appears similar to other aldo-keto reductases, the substrate-binding pocket contains several charged amino acids (Arg-231 and Arg-327) that distinguish it from previously characterized aldo-keto reductases with respect to size and charge. These differences account for the substrate specificity for 4-carbon acid-aldehydes such as succinic semialdehyde and 2-carboxybenzaldehyde as well as for the idiosyncratic substrate aflatoxin B(1) dialdehyde of this subfamily of enzymes. Structural differences between the AKR7A1 ternary complex and apoenzyme reveal a significant hinged movement of the enzyme involving not only the loops of the structure but also parts of the alpha/beta-barrel most intimately involved in cofactor binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11839745}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11839745 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11839745}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Aldo-keto reductase]]
[[Category: Aldo-keto reductase]]
[[Category: Succinic semialdehyde oxidoreductase]]
[[Category: Succinic semialdehyde oxidoreductase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:03:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:08:50 2008''

Revision as of 03:08, 1 July 2008

Image:1gve.png

Template:STRUCTURE 1gve

AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER

Template:ABSTRACT PUBMED 11839745

About this Structure

1GVE is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily., Kozma E, Brown E, Ellis EM, Lapthorn AJ, J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745

Page seeded by OCA on Tue Jul 1 06:08:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gve"
Personal tools