1gwc

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{{STRUCTURE_1gwc| PDB=1gwc | SCENE= }}
{{STRUCTURE_1gwc| PDB=1gwc | SCENE= }}
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'''THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION'''
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===THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION===
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==Overview==
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Glutathione S-transferases (GSTs) from the phi (GSTF) and tau (GSTU) classes are unique to plants and play important roles in stress tolerance and secondary metabolism as well as catalyzing the detoxification of herbicides in crops and weeds. We have cloned and functionally characterized a group of GSTUs from wheat treated with fenchlorazole-ethyl, a herbicide safener. One of these enzymes, TaGSTU4-4, was highly active in conjugating the chemically distinct wheat herbicides fenoxaprop and dimethenamid. The structure of TaGSTU4-4 has been determined at 2.2 A resolution in complex with S-hexylglutathione. This enzyme is the first tau class GST structure to be determined and most closely resembles the omega class GSTs, but without the unique N-terminal extension or active site cysteine. The X-ray structure identifies key amino acid residues in the hydrophobic binding site and provides insights into the substrate specificity of these enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 12033934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12033934}}
==About this Structure==
==About this Structure==
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[[Category: Plant]]
[[Category: Plant]]
[[Category: Tau class]]
[[Category: Tau class]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:05:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:12:43 2008''

Revision as of 03:12, 1 July 2008

Image:1gwc.png

Template:STRUCTURE 1gwc

THE STRUCTURE OF A TAU CLASS GLUTATHIONE S-TRANSFERASE FROM WHEAT, ACTIVE IN HERBICIDE DETOXIFICATION

Template:ABSTRACT PUBMED 12033934

About this Structure

1GWC is a Single protein structure of sequence from Aegilops tauschii. Full crystallographic information is available from OCA.

Reference

Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification., Thom R, Cummins I, Dixon DP, Edwards R, Cole DJ, Lapthorn AJ, Biochemistry. 2002 Jun 4;41(22):7008-20. PMID:12033934

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