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1gyf

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[[Image:1gyf.gif|left|200px]]
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{{STRUCTURE_1gyf| PDB=1gyf | SCENE= }}
{{STRUCTURE_1gyf| PDB=1gyf | SCENE= }}
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'''GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN'''
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===GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN===
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==Overview==
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T cell activation through the CD2 cell surface receptor is transmitted by proline-rich sequences within its cytoplasmic tail. A membrane-proximal proline-rich tandem repeat, involved in cytokine production, is recognized by the intracellular CD2 binding protein CD2BP2. We solved the solution structure of the CD2 binding domain of CD2BP2, which we name the glycine-tyrosine-phenylalanine (GYF) domain. The GYF sequence is part of a structurally unique bulge-helix-bulge motif that constitutes the major binding site for the CD2 tail. A hydrophobic surface patch is created by motif residues that are highly conserved among a variety of proteins from diverse eukaryotic species. Thus, the architecture of the GYF domain may be widely used in protein-protein associations.
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(as it appears on PubMed at http://www.pubmed.gov), where 10404223 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10404223}}
==About this Structure==
==About this Structure==
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1GYF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYF OCA].
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1GYF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYF OCA].
==Reference==
==Reference==
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[[Category: Proline-rich sequence recognition]]
[[Category: Proline-rich sequence recognition]]
[[Category: T cell signaling]]
[[Category: T cell signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:10:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:18:55 2008''

Revision as of 03:18, 1 July 2008

Image:1gyf.png

Template:STRUCTURE 1gyf

GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN

Template:ABSTRACT PUBMED 10404223

About this Structure

1GYF is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences., Freund C, Dotsch V, Nishizawa K, Reinherz EL, Wagner G, Nat Struct Biol. 1999 Jul;6(7):656-60. PMID:10404223

Page seeded by OCA on Tue Jul 1 06:18:55 2008

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