1gzx

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{{Seed}}
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{{STRUCTURE_1gzx| PDB=1gzx | SCENE= }}
{{STRUCTURE_1gzx| PDB=1gzx | SCENE= }}
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'''OXY T STATE HAEMOGLOBIN: OXYGEN BOUND AT ALL FOUR HAEMS'''
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===OXY T STATE HAEMOGLOBIN: OXYGEN BOUND AT ALL FOUR HAEMS===
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==Overview==
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The cooperative binding of oxygen by haemoglobin results from restraints on ligand binding in the T state. The unfavourable interactions made by the ligands at the haems destabilise the T state and favour the high affinity R state. The T &lt;==&gt; R equilibrium leads, in the presence of a ligand, to a rapid increase in the R state population and therefore generates cooperative binding. There is now considerable understanding of this phenomenon, but the interactions that reduce ligand affinity in the T state have not yet been fully explored, owing to the difficulties in preparing T state haemoglobin crystals in which all the subunits are oxygenated. A protocol has been developed to oxygenate deoxy T state adult human haemoglobin (HbA) crystals in air at 4 C at all four haems without significant loss of crystalline order. The X-ray crystal structure, determined to 2.1 A spacing, shows significant changes in the alpha and beta haem pockets as well as changes at the alpha(1)beta(2) interface in the direction of the R quaternary structure. Most of the shifts and deviations from deoxy T state HbA are similar to, but larger than, those previously observed in the T state met and other partially liganded T state forms. They provide clear evidence of haem-haem interaction in the T state.
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(as it appears on PubMed at http://www.pubmed.gov), where 8642597 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8642597}}
==About this Structure==
==About this Structure==
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[[Category: Oxygen binding]]
[[Category: Oxygen binding]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:14:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:23:29 2008''

Revision as of 03:23, 1 July 2008

Image:1gzx.png

Template:STRUCTURE 1gzx

OXY T STATE HAEMOGLOBIN: OXYGEN BOUND AT ALL FOUR HAEMS

Template:ABSTRACT PUBMED 8642597

About this Structure

1GZX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of T state haemoglobin with oxygen bound at all four haems., Paoli M, Liddington R, Tame J, Wilkinson A, Dodson G, J Mol Biol. 1996 Mar 8;256(4):775-92. PMID:8642597

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