1h0m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1h0m.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1h0m.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1h0m| PDB=1h0m | SCENE= }}
{{STRUCTURE_1h0m| PDB=1h0m | SCENE= }}
-
'''THREE-DIMENSIONAL STRUCTURE OF THE QUORUM SENSING PROTEIN TRAR BOUND TO ITS AUTOINDUCER AND TO ITS TARGET DNA'''
+
===THREE-DIMENSIONAL STRUCTURE OF THE QUORUM SENSING PROTEIN TRAR BOUND TO ITS AUTOINDUCER AND TO ITS TARGET DNA===
-
==Overview==
+
<!--
-
The quorum sensing system allows bacteria to sense their cell density and initiate an altered pattern of gene expression after a sufficient quorum of cells has accumulated. In Agrobacterium tumefaciens, quorum sensing controls conjugal transfer of the tumour- inducing plasmid, responsible for plant crown gall disease. The core components of this system are the transcriptional regulator TraR and its inducing ligand N-(3-oxo-octanoyl)-L-homoserine lactone. This complex binds DNA and activates gene expression. We have determined the crystal structure of TraR in complex with its autoinducer and target DNA (PDB code 1h0m). The protein is dimeric, with each monomer composed of an N-terminal domain, which binds the ligand in an enclosed cavity far from the dimerization region, and a C-terminal domain, which binds DNA via a helix-turn-helix motif. The structure reveals an asymmetric homodimer, with one monomer longer than the other. The N-terminal domain resembles GAF/PAS domains, normally fused to catalytic signalling domains. In TraR, the gene fusion is between a GAF/PAS domain and a DNA-binding domain, resulting in a specific transcriptional regulator involved in quorum sensing.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12198141}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12198141 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12198141}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Transcriptional regulator]]
[[Category: Transcriptional regulator]]
[[Category: Trar]]
[[Category: Trar]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:15:43 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:25:21 2008''

Revision as of 03:25, 1 July 2008

Image:1h0m.png


PDB ID 1h0m

Drag the structure with the mouse to rotate
1h0m, resolution 3.00Å ()
Ligands: ,
Non-Standard Residues:
Related: 1l3l
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



THREE-DIMENSIONAL STRUCTURE OF THE QUORUM SENSING PROTEIN TRAR BOUND TO ITS AUTOINDUCER AND TO ITS TARGET DNA

Template:ABSTRACT PUBMED 12198141

About this Structure

1H0M is a Protein complex structure of sequences from Agrobacterium tumefaciens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA., Vannini A, Volpari C, Gargioli C, Muraglia E, Cortese R, De Francesco R, Neddermann P, Marco SD, EMBO J. 2002 Sep 2;21(17):4393-401. PMID:12198141

Page seeded by OCA on Tue Jul 1 06:25:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h0m"
Personal tools