1h2b

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{{Seed}}
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{{STRUCTURE_1h2b| PDB=1h2b | SCENE= }}
{{STRUCTURE_1h2b| PDB=1h2b | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ALCOHOL DEHYDROGENASE FROM THE HYPERTHERMOPHILIC ARCHAEON AEROPYRUM PERNIX AT 1.65A RESOLUTION'''
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===CRYSTAL STRUCTURE OF THE ALCOHOL DEHYDROGENASE FROM THE HYPERTHERMOPHILIC ARCHAEON AEROPYRUM PERNIX AT 1.65A RESOLUTION===
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==Overview==
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The structure of the recombinant medium chain alcohol dehydrogenase (ADH) from the hyperthermophilic archaeon Aeropyrum pernix has been solved by the multiple anomalous dispersion technique using the signal from the naturally occurring zinc ions. The enzyme is a tetramer with 222 point group symmetry. The ADH monomer is formed from a catalytic and a cofactor-binding domain, with the overall fold similar to previously solved ADH structures. The 1.62 A resolution A.pernix ADH structure is that of the holo form, with the cofactor NADH bound into the cleft between the two domains. The electron density found in the active site has been interpreted to be octanoic acid, which has been shown to be an inhibitor of the enzyme. This inhibitor is positioned with its carbonyl oxygen atom forming the fourth ligand of the catalytic zinc ion. The structural zinc ion of each monomer is present at only partial occupancy and in its absence a disulfide bond is formed. The enhanced thermal stability of the A.pernix ADH is thought to arise primarily from increased ionic and hydrophobic interactions on the subunit interfaces.
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The line below this paragraph, {{ABSTRACT_PUBMED_12927540}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12927540 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12927540}}
==About this Structure==
==About this Structure==
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[[Category: Hyperthermophile]]
[[Category: Hyperthermophile]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:20:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:30:34 2008''

Revision as of 03:30, 1 July 2008

Image:1h2b.png

Template:STRUCTURE 1h2b

CRYSTAL STRUCTURE OF THE ALCOHOL DEHYDROGENASE FROM THE HYPERTHERMOPHILIC ARCHAEON AEROPYRUM PERNIX AT 1.65A RESOLUTION

Template:ABSTRACT PUBMED 12927540

About this Structure

1H2B is a Single protein structure of sequence from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix., Guy JE, Isupov MN, Littlechild JA, J Mol Biol. 2003 Aug 29;331(5):1041-51. PMID:12927540

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