1hci

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[[Image:1hci.gif|left|200px]]
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{{STRUCTURE_1hci| PDB=1hci | SCENE= }}
{{STRUCTURE_1hci| PDB=1hci | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ'''
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===CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ===
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==Overview==
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BACKGROUND: Alpha-actinin is a ubiquitously expressed protein found in numerous actin structures. It consists of an N-terminal actin binding domain, a central rod domain, and a C-terminal domain and functions as a homodimer to cross-link actin filaments. The rod domain determines the distance between cross-linked actin filaments and also serves as an interaction site for several cytoskeletal and signaling proteins. RESULTS: We report here the crystal structure of the alpha-actinin rod. The structure is a twisted antiparallel dimer that contains a conserved acidic surface. CONCLUSIONS: The novel features revealed by the structure allow prediction of the orientation of parallel and antiparallel cross-linked actin filaments in relation to alpha-actinin. The conserved acidic surface is a possible interaction site for several cytoplasmic tails of transmembrane proteins involved in the recruitment of alpha-actinin to the plasma membrane.
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The line below this paragraph, {{ABSTRACT_PUBMED_11470434}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11470434 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11470434}}
==About this Structure==
==About this Structure==
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[[Category: Triple-helix coiled coil]]
[[Category: Triple-helix coiled coil]]
[[Category: Z-line]]
[[Category: Z-line]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:41:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:59:18 2008''

Revision as of 04:59, 1 July 2008

Image:1hci.png

Template:STRUCTURE 1hci

CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ

Template:ABSTRACT PUBMED 11470434

About this Structure

1HCI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the alpha-actinin rod reveals an extensive torsional twist., Ylanne J, Scheffzek K, Young P, Saraste M, Structure. 2001 Jul 3;9(7):597-604. PMID:11470434

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