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1hur

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{{STRUCTURE_1hur| PDB=1hur | SCENE= }}
{{STRUCTURE_1hur| PDB=1hur | SCENE= }}
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'''HUMAN ADP-RIBOSYLATION FACTOR 1 COMPLEXED WITH GDP, FULL LENGTH NON-MYRISTOYLATED'''
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===HUMAN ADP-RIBOSYLATION FACTOR 1 COMPLEXED WITH GDP, FULL LENGTH NON-MYRISTOYLATED===
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==Overview==
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ADP-ribosylation factors (ARFs) are essential and ubiquitous in eukaryotes, being involved in vesicular transport and functioning as an activator of phospholipase D (refs 1, 2) and cholera toxin. The functions of ARF proteins in membrane traffic and organelle integrity are intimately tied to its reversible association with membranes and specific interactions with membrane phospholipids. One common feature of these functions is their regulation by the binding and hydrolysis of GTP. Here we report the three-dimensional structure of full-length human ARF1 (M(r) 21,000) in its GDP-bound non-myristoylated form. The presence of a unique amino-terminal alpha-helix and loop, together with differences in Mg2+ ligation and the existence of a non-crystallographic dimer, set this structure apart from other GTP-binding proteins. These features provide a structural basis for the GTP-dependent modulation of membrane affinity, the lack of intrinsic GTPase activity, and the nature of effector binding surfaces.
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(as it appears on PubMed at http://www.pubmed.gov), where 7990966 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7990966}}
==About this Structure==
==About this Structure==
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[[Category: Membrane traffickin]]
[[Category: Membrane traffickin]]
[[Category: Non-myristoylated]]
[[Category: Non-myristoylated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:14:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:44:34 2008''

Revision as of 05:44, 1 July 2008

Image:1hur.png

Template:STRUCTURE 1hur

HUMAN ADP-RIBOSYLATION FACTOR 1 COMPLEXED WITH GDP, FULL LENGTH NON-MYRISTOYLATED

Template:ABSTRACT PUBMED 7990966

About this Structure

1HUR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human ADP-ribosylation factor 1 complexed with GDP., Amor JC, Harrison DH, Kahn RA, Ringe D, Nature. 1994 Dec 15;372(6507):704-8. PMID:7990966

Page seeded by OCA on Tue Jul 1 08:44:34 2008

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