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1hwq

From Proteopedia

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[[Image:1hwq.gif|left|200px]]
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{{Seed}}
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[[Image:1hwq.png|left|200px]]
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{{STRUCTURE_1hwq| PDB=1hwq | SCENE= }}
{{STRUCTURE_1hwq| PDB=1hwq | SCENE= }}
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'''SOLUTION STRUCTURE OF THE VS RIBOZYME SUBSTRATE STEM-LOOP'''
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===SOLUTION STRUCTURE OF THE VS RIBOZYME SUBSTRATE STEM-LOOP===
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==Overview==
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The VS ribozyme is a 154 nucleotide sequence found in certain natural strains of Neurospora. The RNA can be divided into a substrate and a catalytic domain. Here we present the solution structure of the substrate RNA that is cleaved in a trans reaction by the catalytic domain in the presence of Mg2+. The 30 nucleotide substrate RNA forms a compact helix capped by a flexible loop. The cleavage site bulge contains three non-canonical base-pairs, including an A+.C pair with a protonated adenine. This adenine (A622) is a pH controlled conformational switch that opens up the internal loop at higher pH. The possible significance of this switch for substrate recognition and cleavage is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_11350168}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11350168 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11350168}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWQ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWQ OCA].
==Reference==
==Reference==
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[[Category: Tandem ga]]
[[Category: Tandem ga]]
[[Category: Vs ribozyme]]
[[Category: Vs ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:18:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:01:56 2008''

Revision as of 07:01, 1 July 2008

Image:1hwq.png

Template:STRUCTURE 1hwq

SOLUTION STRUCTURE OF THE VS RIBOZYME SUBSTRATE STEM-LOOP

Template:ABSTRACT PUBMED 11350168

About this Structure

Full experimental information is available from OCA.

Reference

A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNA., Flinders J, Dieckmann T, J Mol Biol. 2001 May 11;308(4):665-79. PMID:11350168

Page seeded by OCA on Tue Jul 1 10:01:56 2008

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