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1i1a

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[[Image:1i1a.gif|left|200px]]
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{{STRUCTURE_1i1a| PDB=1i1a | SCENE= }}
{{STRUCTURE_1i1a| PDB=1i1a | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC'''
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===CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC===
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==Overview==
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The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across epithelia, binding IgG in acidic vesicles (pH &lt; or = 6.5) and releasing IgG in the blood at pH 7.4. Well-ordered FcRn/Fc crystals are prevented by the formation of "oligomeric ribbons" of FcRn dimers bridged by Fc homodimers, thus we crystallized a 1:1 complex between rat FcRn and a heterodimeric Fc containing only one FcRn binding site. The 2.8 A complex structure demonstrates that FcRn uses its alpha2 and beta2-microglobulin domains and carbohydrate to interact with the Fc C(gamma)2-C(gamma)3 interface. The structure reveals conformational changes in Fc and three titratable salt bridges that confer pH-dependent binding, and can be used to guide rational design of therapeutic IgGs with longer serum half-lives.
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The line below this paragraph, {{ABSTRACT_PUBMED_11336709}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11336709 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11336709}}
==About this Structure==
==About this Structure==
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[[Category: Ig constant domain]]
[[Category: Ig constant domain]]
[[Category: Mhc class i fold]]
[[Category: Mhc class i fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:27:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:15:52 2008''

Revision as of 07:15, 1 July 2008

Image:1i1a.png

Template:STRUCTURE 1i1a

CRYSTAL STRUCTURE OF THE NEONATAL FC RECEPTOR COMPLEXED WITH A HETERODIMERIC FC

Template:ABSTRACT PUBMED 11336709

About this Structure

1I1A is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding., Martin WL, West AP Jr, Gan L, Bjorkman PJ, Mol Cell. 2001 Apr;7(4):867-77. PMID:11336709

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