1i9e

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[[Image:1i9e.jpg|left|200px]]
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{{Seed}}
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[[Image:1i9e.png|left|200px]]
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{{STRUCTURE_1i9e| PDB=1i9e | SCENE= }}
{{STRUCTURE_1i9e| PDB=1i9e | SCENE= }}
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'''TCR DOMAIN'''
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===TCR DOMAIN===
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==Overview==
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The T-cell receptor (TCR) is a heterodimeric cell-surface protein consisting of two chains, alpha and beta, each of which is composed of a variable (V) and a constant (C) domain. Crystals of the isolated V(alpha) domain of the murine TCR 2C were grown by serendipity from a solution containing the extracellular domains of the intact TCR 2C and CD3 gamma epsilon-chains. The V(alpha) crystal structure shows how crystal packing can substitute for another V(alpha) domain in a different fashion from that observed in V(alpha)/V(alpha) homodimer and V(alpha)/V(beta) heterodimer structures. Significant conformational changes occur in the CDR3 and beta(3)beta(4) loops that normally form part of the dimer interface. The monomeric V(alpha) domain provides the unique opportunity to study the effect of dimerization on the conformation of the unliganded complementarity-determining regions (CDR) of a TCR. This structure of an individual V(alpha) module has implications for stability and bioengineering of isolated antibody and immunoglobulin domains.
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The line below this paragraph, {{ABSTRACT_PUBMED_11724527}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11724527 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11724527}}
==About this Structure==
==About this Structure==
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[[Category: Ig-like domain]]
[[Category: Ig-like domain]]
[[Category: T cell receptor]]
[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:44:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:37:14 2008''

Revision as of 07:37, 1 July 2008

Image:1i9e.png

Template:STRUCTURE 1i9e

TCR DOMAIN

Template:ABSTRACT PUBMED 11724527

About this Structure

1I9E is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor., Rudolph MG, Huang M, Teyton L, Wilson IA, J Mol Biol. 2001 Nov 16;314(1):1-8. PMID:11724527

Page seeded by OCA on Tue Jul 1 10:37:14 2008

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