1iaj

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[[Image:1iaj.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1iaj| PDB=1iaj | SCENE= }}
{{STRUCTURE_1iaj| PDB=1iaj | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)'''
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===CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)===
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==Overview==
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Transient receptor potential (TRP) channels modulate calcium levels in eukaryotic cells in response to external signals. A novel transient receptor potential channel has the ability to phosphorylate itself and other proteins on serine and threonine residues. The catalytic domain of this channel kinase has no detectable sequence similarity to classical eukaryotic protein kinases and is essential for channel function. The structure of the kinase domain, reported here, reveals unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains. The inclusion of the channel kinase catalytic domain within the eukaryotic protein kinase superfamily indicates a significantly wider distribution for this group of signaling proteins than suggested previously by sequence comparisons alone.
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The line below this paragraph, {{ABSTRACT_PUBMED_11389851}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11389851 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11389851}}
==About this Structure==
==About this Structure==
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[[Category: Atp-grasp fold]]
[[Category: Atp-grasp fold]]
[[Category: Protein kinase like fold]]
[[Category: Protein kinase like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:46:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:10 2008''

Revision as of 07:40, 1 July 2008

Image:1iaj.png

Template:STRUCTURE 1iaj

CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)

Template:ABSTRACT PUBMED 11389851

About this Structure

1IAJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity., Yamaguchi H, Matsushita M, Nairn AC, Kuriyan J, Mol Cell. 2001 May;7(5):1047-57. PMID:11389851

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