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1iaw

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[[Image:1iaw.gif|left|200px]]
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{{STRUCTURE_1iaw| PDB=1iaw | SCENE= }}
{{STRUCTURE_1iaw| PDB=1iaw | SCENE= }}
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'''CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA'''
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===CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA===
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==Overview==
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NaeI, a novel DNA endonuclease, shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43. The NaeI-DNA structure demonstrates that each of the two domains of NaeI recognizes one molecule of DNA duplex. DNA recognition induces dramatic rearrangements: narrowing the binding site of the Topo domain 16 A to grip DNA, widening that of the Endo domain 8 A to encircle and bend DNA 45 degrees for cleavage, and completely rebuilding the homodimer interface. The NaeI-DNA structure presents the first example of novel recognition of two copies of one DNA sequence by two different amino acid sequences and two different structural motifs in one polypeptide.
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(as it appears on PubMed at http://www.pubmed.gov), where 11473254 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11473254}}
==About this Structure==
==About this Structure==
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[[Category: Topal, M D.]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:47:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:41:12 2008''

Revision as of 07:41, 1 July 2008

Image:1iaw.png

Template:STRUCTURE 1iaw

CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA

Template:ABSTRACT PUBMED 11473254

About this Structure

1IAW is a Single protein structure of sequence from Lechevalieria aerocolonigenes. Full crystallographic information is available from OCA.

Reference

Structure of NaeI-DNA complex reveals dual-mode DNA recognition and complete dimer rearrangement., Huai Q, Colandene JD, Topal MD, Ke H, Nat Struct Biol. 2001 Aug;8(8):665-9. PMID:11473254

Page seeded by OCA on Tue Jul 1 10:41:12 2008

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