1ic9

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[[Image:1ic9.gif|left|200px]]
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{{Seed}}
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[[Image:1ic9.png|left|200px]]
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{{STRUCTURE_1ic9| PDB=1ic9 | SCENE= }}
{{STRUCTURE_1ic9| PDB=1ic9 | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX'''
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===NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX===
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==Overview==
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Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
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The line below this paragraph, {{ABSTRACT_PUBMED_11373623}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11373623 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11373623}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
==Reference==
==Reference==
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[[Category: Ottesen, J J.]]
[[Category: Ottesen, J J.]]
[[Category: Three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
[[Category: Three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:02 2008''

Revision as of 07:45, 1 July 2008

Image:1ic9.png

Template:STRUCTURE 1ic9

NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX

Template:ABSTRACT PUBMED 11373623

About this Structure

Full experimental information is available from OCA.

Reference

Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623

Page seeded by OCA on Tue Jul 1 10:45:02 2008

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