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1ica

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[[Image:1ica.gif|left|200px]]
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{{STRUCTURE_1ica| PDB=1ica | SCENE= }}
{{STRUCTURE_1ica| PDB=1ica | SCENE= }}
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'''REFINED THREE-DIMENSIONAL STRUCTURE OF INSECT DEFENSIN A'''
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===REFINED THREE-DIMENSIONAL STRUCTURE OF INSECT DEFENSIN A===
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==Overview==
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BACKGROUND: Insect defensin A is a basic 4 kDa protein secreted by Phormia terranovae larvae in response to bacterial challenges or injuries. Previous biological tests suggest that the bacterial cytoplasmic membrane is the target of defensin A. The structural study of this protein is the first step towards establishing a structure-activity relationship and forms the basis for understanding its antibiotic activity at the molecular level. RESULTS: We describe a refined model of the three-dimensional structure of defensin A derived from an extensive analysis of 786 inter-proton nuclear Overhauser effects. The backbone fold involves an N-terminal loop and an alpha-helical fragment followed by an antiparallel beta-structure. The helix and the beta-structure are connected by two of the three disulphide bridges present in defensin A, forming a so-called 'cysteine-stabilized alpha beta' (CS alpha beta) motif. The N-terminal loop, which is locally well defined, can occupy different positions with respect to the other moieties of the molecule. CONCLUSIONS: The CS alpha beta motif, which forms the core of the defensin A structure, appears to be a common organization for several families of small proteins with toxic properties. The distribution of amino acid side chains in the protein structure creates several hydrophobic or hydrophilic patches. This leads us to propose that the initial step in the action of positively charged defensin A molecules with cytoplasmic membranes may involve interactions with acidic phospholipids.
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(as it appears on PubMed at http://www.pubmed.gov), where 7663941 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7663941}}
==About this Structure==
==About this Structure==
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1ICA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Protophormia_terraenovae Protophormia terraenovae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICA OCA].
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1ICA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Protophormia_terraenovae Protophormia terraenovae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICA OCA].
==Reference==
==Reference==
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[[Category: Vovelle, F.]]
[[Category: Vovelle, F.]]
[[Category: Antibacterial protein]]
[[Category: Antibacterial protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:07 2008''

Revision as of 07:45, 1 July 2008

Image:1ica.png

Template:STRUCTURE 1ica

REFINED THREE-DIMENSIONAL STRUCTURE OF INSECT DEFENSIN A

Template:ABSTRACT PUBMED 7663941

About this Structure

1ICA is a Single protein structure of sequence from Protophormia terraenovae. Full experimental information is available from OCA.

Reference

Refined three-dimensional solution structure of insect defensin A., Cornet B, Bonmatin JM, Hetru C, Hoffmann JA, Ptak M, Vovelle F, Structure. 1995 May 15;3(5):435-48. PMID:7663941

Page seeded by OCA on Tue Jul 1 10:45:07 2008

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