1ify

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{{STRUCTURE_1ify| PDB=1ify | SCENE= }}
{{STRUCTURE_1ify| PDB=1ify | SCENE= }}
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'''Solution Structure of the Internal UBA Domain of HHR23A'''
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===Solution Structure of the Internal UBA Domain of HHR23A===
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==Overview==
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UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signaling via protein kinases. The human homologue of yeast Rad23A (HHR23A) is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of HHR23A UBA(2) showed that the domain forms a compact three-helix bundle. We report the structure of the internal UBA(1) domain of HHR23A. Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch. The structural similarity between UBA(1) and UBA(2), in spite of their low level of sequence conservation, leads us to conclude that the structural variability of UBA domains in general is likely to be rather small. On the basis of the structural similarities as well as analysis of sequence conservation, we predict that this hydrophobic surface patch is a common protein-interacting surface present in diverse UBA domains. Furthermore, accumulating evidence that ubiquitin binds to UBA domains leads us to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin. Detailed comparison of the structures of the two UBA domains, combined with previous mutagenesis studies, indicates that the binding site of HIV-1 Vpr on UBA(2) does not completely overlap the ubiquitin binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 12079361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12079361}}
==About this Structure==
==About this Structure==
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1IFY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IFY OCA].
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1IFY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IFY OCA].
==Reference==
==Reference==
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[[Category: Ubiquitin associated domain]]
[[Category: Ubiquitin associated domain]]
[[Category: Ubiquitin proteosome pathway]]
[[Category: Ubiquitin proteosome pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:55:19 2008''

Revision as of 07:55, 1 July 2008

Image:1ify.png

Template:STRUCTURE 1ify

Solution Structure of the Internal UBA Domain of HHR23A

Template:ABSTRACT PUBMED 12079361

About this Structure

1IFY is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions., Mueller TD, Feigon J, J Mol Biol. 2002 Jun 21;319(5):1243-55. PMID:12079361

Page seeded by OCA on Tue Jul 1 10:55:19 2008

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