1irj

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[[Image:1irj.gif|left|200px]]
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{{STRUCTURE_1irj| PDB=1irj | SCENE= }}
{{STRUCTURE_1irj| PDB=1irj | SCENE= }}
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'''Crystal Structure of the MRP14 complexed with CHAPS'''
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===Crystal Structure of the MRP14 complexed with CHAPS===
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==Overview==
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Human MRP14 (hMRP14) is a Ca(2+)-binding protein from the S100 family of proteins. This protein is co-expressed with human MRP8 (hMRP8), a homologue protein in myeloid cells, and plays an indispensable role in Ca(2+)-dependent functions during inflammation. This role includes the activation of Mac-1, the beta(2) integrin which is involved in neutrophil adhesion to endothelial cells. The crystal structure of the holo form of hMRP14 was analyzed at 2.1 A resolution. hMRP14 is distinguished from other S100 member proteins by its long C-terminal region, and its structure shows that the region is extensively flexible. In this crystal structure of hMRP14, Chaps molecules bind to the hinge region that connects two EF-hand motifs, which suggests that this region is a target-binding site of this protein. Based on a structural comparison of hMRP14 with hMRP8 and human S100A12 (hS100A12) that is another homologue protein, the character of MRP8/14 hetero-complex and the functional significance of the flexibility of the C-terminal region of hMRP14 are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_11851337}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11851337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11851337}}
==About this Structure==
==About this Structure==
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[[Category: Mrp14]]
[[Category: Mrp14]]
[[Category: S100a9]]
[[Category: S100a9]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:19:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:52:25 2008''

Revision as of 10:52, 1 July 2008

Image:1irj.png

Template:STRUCTURE 1irj

Crystal Structure of the MRP14 complexed with CHAPS

Template:ABSTRACT PUBMED 11851337

About this Structure

1IRJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process., Itou H, Yao M, Fujita I, Watanabe N, Suzuki M, Nishihira J, Tanaka I, J Mol Biol. 2002 Feb 15;316(2):265-76. PMID:11851337

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