1isn

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{{STRUCTURE_1isn| PDB=1isn | SCENE= }}
{{STRUCTURE_1isn| PDB=1isn | SCENE= }}
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'''Crystal structure of merlin FERM domain'''
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===Crystal structure of merlin FERM domain===
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==Overview==
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Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying notable features of the electrostatic surface potentials, although the overall surface potentials similar to those of ezrin/radixin/moesin (ERM) proteins indicate electrostatic membrane association. The structure also is consistent with inactivation mechanisms caused by the pathogenic mutations associated with NF2.
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(as it appears on PubMed at http://www.pubmed.gov), where 11756419 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11756419}}
==About this Structure==
==About this Structure==
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[[Category: Tsukita, S.]]
[[Category: Tsukita, S.]]
[[Category: Ferm domain]]
[[Category: Ferm domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:21:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:55:50 2008''

Revision as of 10:55, 1 July 2008

Image:1isn.png

Template:STRUCTURE 1isn

Crystal structure of merlin FERM domain

Template:ABSTRACT PUBMED 11756419

About this Structure

1ISN is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain., Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T, J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419

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