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1itu

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[[Image:1itu.gif|left|200px]]
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{{Seed}}
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[[Image:1itu.png|left|200px]]
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{{STRUCTURE_1itu| PDB=1itu | SCENE= }}
{{STRUCTURE_1itu| PDB=1itu | SCENE= }}
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'''HUMAN RENAL DIPEPTIDASE COMPLEXED WITH CILASTATIN'''
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===HUMAN RENAL DIPEPTIDASE COMPLEXED WITH CILASTATIN===
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==Overview==
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Human renal dipeptidase is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. The crystal structures of the saccharide-trimmed enzyme are determined as unliganded and inhibitor-liganded forms. They are informative for designing new antibiotics that are not hydrolyzed by this enzyme. The active site in each of the (alpha/beta)(8) barrel subunits of the homodimeric molecule is composed of binuclear zinc ions bridged by the Glu125 side-chain located at the bottom of the barrel, and it faces toward the microvillar membrane of a kidney tubule. A dipeptidyl moiety of the therapeutically used cilastatin inhibitor is fully accommodated in the active-site pocket, which is small enough for precise recognition of dipeptide substrates. The barrel and active-site architectures utilizing catalytic metal ions exhibit unexpected similarities to those of the murine adenosine deaminase and the catalytic domain of the bacterial urease.
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The line below this paragraph, {{ABSTRACT_PUBMED_12144777}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12144777 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12144777}}
==About this Structure==
==About this Structure==
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[[Category: Membrane-bound]]
[[Category: Membrane-bound]]
[[Category: Zinc protease beta-lactamase]]
[[Category: Zinc protease beta-lactamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:24:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:59:10 2008''

Revision as of 10:59, 1 July 2008

Image:1itu.png

Template:STRUCTURE 1itu

HUMAN RENAL DIPEPTIDASE COMPLEXED WITH CILASTATIN

Template:ABSTRACT PUBMED 12144777

About this Structure

1ITU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis., Nitanai Y, Satow Y, Adachi H, Tsujimoto M, J Mol Biol. 2002 Aug 9;321(2):177-84. PMID:12144777

Page seeded by OCA on Tue Jul 1 13:59:10 2008

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