1izn

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{{STRUCTURE_1izn| PDB=1izn | SCENE= }}
{{STRUCTURE_1izn| PDB=1izn | SCENE= }}
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'''Crystal Structure of Actin Filament Capping Protein CapZ'''
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===Crystal Structure of Actin Filament Capping Protein CapZ===
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==Overview==
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Capping protein, a heterodimeric protein composed of alpha and beta subunits, is a key cellular component regulating actin filament assembly and organization. It binds to the barbed ends of the filaments and works as a 'cap' by preventing the addition and loss of actin monomers at the end. Here we describe the crystal structure of the chicken sarcomeric capping protein CapZ at 2.1 A resolution. The structure shows a striking resemblance between the alpha and beta subunits, so that the entire molecule has a pseudo 2-fold rotational symmetry. CapZ has a pair of mobile extensions for actin binding, one of which also provides concomitant binding to another protein for the actin filament targeting. The mobile extensions probably form flexible links to the end of the actin filament with a pseudo 2(1) helical symmetry, enabling the docking of the two in a symmetry mismatch.
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(as it appears on PubMed at http://www.pubmed.gov), where 12660160 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12660160}}
==About this Structure==
==About this Structure==
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[[Category: Capping protein]]
[[Category: Capping protein]]
[[Category: Heterodimer]]
[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:37:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:16:43 2008''

Revision as of 11:16, 1 July 2008

Image:1izn.png

Template:STRUCTURE 1izn

Crystal Structure of Actin Filament Capping Protein CapZ

Template:ABSTRACT PUBMED 12660160

About this Structure

1IZN is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of CapZ: structural basis for actin filament barbed end capping., Yamashita A, Maeda K, Maeda Y, EMBO J. 2003 Apr 1;22(7):1529-38. PMID:12660160

Page seeded by OCA on Tue Jul 1 14:16:43 2008

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