1j6s

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{{STRUCTURE_1j6s| PDB=1j6s | SCENE= }}
{{STRUCTURE_1j6s| PDB=1j6s | SCENE= }}
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'''Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads'''
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===Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads===
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==Overview==
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Purine-rich regions in DNA and RNA may contain both guanines and adenines, which have various biological functions. Here we report the crystal structure of an RNA purine-rich fragment containing both guanine and adenine at 1.4 A resolution. Adenines form an adenine tetrad in the N6-H em leader N7 conformation. Substitution of an adenine tetrad in the guanine tetraplex does not change the global conformation but introduces irregularity in both the hydrogen bonding interaction pattern in the groove and the metal ion binding pattern in the central cavity of the tetraplex. The irregularity in groove binding may be critical for specific binding in tetraplexes. The formation of G-U octads provides a mechanism for interaction in the groove. Ba(2+) ions prefer to bind guanine tetrads, and adenine tetrads can only be bound by Na(+) ions, illustrating the binding selectivity of metal ions for the tetraplex.
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{{ABSTRACT_PUBMED_12842044}}
==About this Structure==
==About this Structure==
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[[Category: Tetraplex]]
[[Category: Tetraplex]]
[[Category: U-tetrad]]
[[Category: U-tetrad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:51:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:33:19 2008''

Revision as of 11:33, 1 July 2008

Image:1j6s.png

Template:STRUCTURE 1j6s

Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads

Template:ABSTRACT PUBMED 12842044

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes., Pan B, Xiong Y, Shi K, Deng J, Sundaralingam M, Structure. 2003 Jul;11(7):815-23. PMID:12842044

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