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1j9l

From Proteopedia

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[[Image:1j9l.gif|left|200px]]
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{{STRUCTURE_1j9l| PDB=1j9l | SCENE= }}
{{STRUCTURE_1j9l| PDB=1j9l | SCENE= }}
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'''CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE'''
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===CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE===
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==Overview==
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Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.
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(as it appears on PubMed at http://www.pubmed.gov), where 11524683 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524683}}
==About this Structure==
==About this Structure==
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[[Category: Sure protein]]
[[Category: Sure protein]]
[[Category: Vanadate complex]]
[[Category: Vanadate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:57:06 2008''
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Revision as of 11:43, 1 July 2008

Image:1j9l.png

Template:STRUCTURE 1j9l

CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH VANADATE

Template:ABSTRACT PUBMED 11524683

About this Structure

1J9L is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:11524683

Page seeded by OCA on Tue Jul 1 14:43:39 2008

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