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1jgd

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{{STRUCTURE_1jgd| PDB=1jgd | SCENE= }}
{{STRUCTURE_1jgd| PDB=1jgd | SCENE= }}
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'''HLA-B*2709 bound to deca-peptide s10R'''
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===HLA-B*2709 bound to deca-peptide s10R===
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==Overview==
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Selected HLA-B27 subtypes are associated with spondyloarthropathies, but the underlying mechanism is not understood. To explain this association in molecular terms, a comparison of peptide-dependent dynamic and structural properties of the differentially disease-associated subtypes HLA-B*2705 and HLA-B*2709 was carried out. These molecules differ only by a single amino acid at the floor of the peptide binding groove. The thermostabilities of a series of HLA-B27 molecules complexed with nonameric and decameric peptides were determined and revealed substantial differences depending on the subtype as well as the residues at the termini of the peptides. In addition we present the crystal structure of the B*2709 subtype complexed with a decameric peptide. This structure provides an explanation for the preference of HLA-B27 for a peptide with an N-terminal arginine as secondary anchor and the lack of preference for tyrosine as peptide C terminus in B*2709. The data show that differences in thermodynamic properties between peptide-complexed HLA-B27 subtypes are correlated with a variety of structural properties.
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(as it appears on PubMed at http://www.pubmed.gov), where 14555655 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14555655}}
==Disease==
==Disease==
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[[Category: Volz, A.]]
[[Category: Volz, A.]]
[[Category: Ziegler, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:12:21 2008''

Revision as of 17:12, 1 July 2008

Image:1jgd.png

Template:STRUCTURE 1jgd

Contents

HLA-B*2709 bound to deca-peptide s10R

Template:ABSTRACT PUBMED 14555655

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1JGD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Thermodynamic and structural analysis of peptide- and allele-dependent properties of two HLA-B27 subtypes exhibiting differential disease association., Hillig RC, Hulsmeyer M, Saenger W, Welfle K, Misselwitz R, Welfle H, Kozerski C, Volz A, Uchanska-Ziegler B, Ziegler A, J Biol Chem. 2004 Jan 2;279(1):652-63. Epub 2003 Oct 10. PMID:14555655

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