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1jij

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[[Image:1jij.jpg|left|200px]]
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{{STRUCTURE_1jij| PDB=1jij | SCENE= }}
{{STRUCTURE_1jij| PDB=1jij | SCENE= }}
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'''Crystal structure of S. aureus TyrRS in complex with SB-239629'''
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===Crystal structure of S. aureus TyrRS in complex with SB-239629===
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==Overview==
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SB-219383 and its analogues are a class of potent and specific inhibitors of bacterial tyrosyl-tRNA synthetases. Crystal structures of these inhibitors have been solved in complex with the tyrosyl-tRNA synthetase from Staphylococcus aureus, the bacterium that is largely responsible for hospital-acquired infections. The full-length enzyme yielded crystals that diffracted to 2.8 A resolution, but a truncated version of the enzyme allowed the resolution to be extended to 2.2 A. These inhibitors not only occupy the known substrate binding sites in unique ways, but also reveal a butyl binding pocket. It was reported that the Bacillus stearothermophilus TyrRS T51P mutant has much increased catalytic activity. The S. aureus enzyme happens to have a proline at position 51. Therefore, our structures may contribute to the understanding of the catalytic mechanism and provide the structural basis for designing novel antimicrobial agents.
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The line below this paragraph, {{ABSTRACT_PUBMED_11567092}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11567092 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11567092}}
==About this Structure==
==About this Structure==
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[[Category: Truncation]]
[[Category: Truncation]]
[[Category: Tyrosyl-trna synthetase]]
[[Category: Tyrosyl-trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:15:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:18:00 2008''

Revision as of 17:18, 1 July 2008

Image:1jij.png

Template:STRUCTURE 1jij

Crystal structure of S. aureus TyrRS in complex with SB-239629

Template:ABSTRACT PUBMED 11567092

About this Structure

1JIJ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors., Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL, Protein Sci. 2001 Oct;10(10):2008-16. PMID:11567092

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