1jjh

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[[Image:1jjh.gif|left|200px]]
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{{STRUCTURE_1jjh| PDB=1jjh | SCENE= }}
{{STRUCTURE_1jjh| PDB=1jjh | SCENE= }}
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'''E2 DNA-binding Domain from Bovine Papillomavirus Type 1'''
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===E2 DNA-binding Domain from Bovine Papillomavirus Type 1===
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==Overview==
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The 2.5 A crystal structures of the DNA-binding domain of the E2 protein from bovine papillomavirus strain 1 and its complex with DNA are presented. E2 is a transcriptional regulatory protein that is also involved in viral DNA replication. It is the structural prototype for a novel class of DNA-binding proteins: dimeric beta-barrels with surface alpha-helices that serve as recognition helices. These helices contain the amino-acid residues involved in sequence-specifying interactions. The E2 proteins from different papillomavirus strains recognize and bind to the same consensus 12 base-pair DNA sequence. However, recent evidence from solution studies points to differences in the mechanisms by which E2 from the related viral strains bovine papillomavirus-1 and human papillomavirus-16 discriminate between DNA targets based on non-contacted nucleotide sequences. This report provides evidence that sequence-specific DNA-binding is accompanied by a rearrangement of protein subunits and deformation of the DNA. These results suggest that, along with DNA sequence-dependent conformational properties, protein subunit orientation plays a significant role in the mechanisms of target selection utilized by E2.
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The line below this paragraph, {{ABSTRACT_PUBMED_9500927}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9500927 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9500927}}
==About this Structure==
==About this Structure==
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[[Category: Dna-binding domain]]
[[Category: Dna-binding domain]]
[[Category: E2]]
[[Category: E2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:17:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:20:23 2008''

Revision as of 17:20, 1 July 2008

Image:1jjh.png

Template:STRUCTURE 1jjh

E2 DNA-binding Domain from Bovine Papillomavirus Type 1

Template:ABSTRACT PUBMED 9500927

About this Structure

1JJH is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.

Reference

Subunit rearrangement accompanies sequence-specific DNA binding by the bovine papillomavirus-1 E2 protein., Hegde RS, Wang AF, Kim SS, Schapira M, J Mol Biol. 1998 Mar 6;276(4):797-808. PMID:9500927

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