1jji

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{{STRUCTURE_1jji| PDB=1jji | SCENE= }}
{{STRUCTURE_1jji| PDB=1jji | SCENE= }}
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'''The Crystal Structure of a Hyper-thermophilic Carboxylesterase from the Archaeon Archaeoglobus fulgidus'''
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===The Crystal Structure of a Hyper-thermophilic Carboxylesterase from the Archaeon Archaeoglobus fulgidus===
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==Overview==
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The crystal structure of AFEST, a novel hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus, complexed with a sulphonyl derivative, has been determined and refined to 2.2 A resolution. This enzyme, which has recently been classified as a member of the hormone- sensitive-lipase (H) group of the esterase/lipase superfamily, presents a canonical alpha/beta hydrolase core, shielded on the C-terminal side by a cap region composed of five alpha-helices. It contains the catalytic triad Ser160, His285 and Asp255, whereby the nucleophile is covalently modified and the oxyanion hole formed by Gly88, Gly89 and Ala161. A structural comparison of AFEST with its mesophilic and thermophilic homologues, Brefeldin A esterase from Bacillus subtilis (BFAE) and EST2 from Alicyclobacillus acidocaldarius, reveals an increase in the number of intramolecular ion pairs and secondary structure content, as well as a significant reduction in loop extensions and ratio of hydrophobic to charged surface area. The variety of structural differences suggests possible strategies for thermostabilization of lipases and esterases with potential industrial applications.
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(as it appears on PubMed at http://www.pubmed.gov), where 11846563 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11846563}}
==About this Structure==
==About this Structure==
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[[Category: Sorrentino, N.]]
[[Category: Sorrentino, N.]]
[[Category: Alpha-beta hydrolase fold]]
[[Category: Alpha-beta hydrolase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:17:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:20:30 2008''

Revision as of 17:20, 1 July 2008

Image:1jji.png

Template:STRUCTURE 1jji

The Crystal Structure of a Hyper-thermophilic Carboxylesterase from the Archaeon Archaeoglobus fulgidus

Template:ABSTRACT PUBMED 11846563

About this Structure

1JJI is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus., De Simone G, Menchise V, Manco G, Mandrich L, Sorrentino N, Lang D, Rossi M, Pedone C, J Mol Biol. 2001 Nov 30;314(3):507-18. PMID:11846563

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