1jjo

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[[Image:1jjo.gif|left|200px]]
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{{Seed}}
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[[Image:1jjo.png|left|200px]]
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{{STRUCTURE_1jjo| PDB=1jjo | SCENE= }}
{{STRUCTURE_1jjo| PDB=1jjo | SCENE= }}
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'''Crystal Structure of Mouse Neuroserpin (Cleaved form)'''
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===Crystal Structure of Mouse Neuroserpin (Cleaved form)===
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==Overview==
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The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.
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The line below this paragraph, {{ABSTRACT_PUBMED_11557034}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11557034 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11557034}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:18:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:20:56 2008''

Revision as of 17:20, 1 July 2008

Image:1jjo.png

Template:STRUCTURE 1jjo

Crystal Structure of Mouse Neuroserpin (Cleaved form)

Template:ABSTRACT PUBMED 11557034

About this Structure

1JJO is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease., Briand C, Kozlov SV, Sonderegger P, Grutter MG, FEBS Lett. 2001 Sep 7;505(1):18-22. PMID:11557034

Page seeded by OCA on Tue Jul 1 20:20:56 2008

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