1jjv

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[[Image:1jjv.gif|left|200px]]
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{{Seed}}
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[[Image:1jjv.png|left|200px]]
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{{STRUCTURE_1jjv| PDB=1jjv | SCENE= }}
{{STRUCTURE_1jjv| PDB=1jjv | SCENE= }}
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'''DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP'''
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===DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP===
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==Overview==
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Dephospho-coenzyme A kinase catalyzes the final step in CoA biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. The protein from Haemophilus influenzae was cloned and expressed, and its crystal structure was determined at 2.0-A resolution in complex with ATP. The protein molecule consists of three domains: the canonical nucleotide-binding domain with a five-stranded parallel beta-sheet, the substrate-binding alpha-helical domain, and the lid domain formed by a pair of alpha-helices. The overall topology of the protein resembles the structures of nucleotide kinases. ATP binds in the P-loop in a manner observed in other kinases. The CoA-binding site is located at the interface of all three domains. The double-pocket structure of the substrate-binding site is unusual for nucleotide kinases. Amino acid residues implicated in substrate binding and catalysis have been identified. The structure analysis suggests large domain movements during the catalytic cycle.
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(as it appears on PubMed at http://www.pubmed.gov), where 11886213 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11886213}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structure 2 function project]]
[[Category: Structure 2 function project]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:18:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:21:24 2008''

Revision as of 17:21, 1 July 2008

Image:1jjv.png

Template:STRUCTURE 1jjv

DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP

Template:ABSTRACT PUBMED 11886213

About this Structure

1JJV is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae., Obmolova G, Teplyakov A, Bonander N, Eisenstein E, Howard AJ, Gilliland GL, J Struct Biol. 2001 Nov;136(2):119-25. PMID:11886213

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