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1jki

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[[Image:1jki.gif|left|200px]]
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{{Seed}}
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[[Image:1jki.png|left|200px]]
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{{STRUCTURE_1jki| PDB=1jki | SCENE= }}
{{STRUCTURE_1jki| PDB=1jki | SCENE= }}
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'''myo-Inositol-1-phosphate Synthase Complexed with an Inhibitor, 2-deoxy-glucitol-6-phosphate'''
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===myo-Inositol-1-phosphate Synthase Complexed with an Inhibitor, 2-deoxy-glucitol-6-phosphate===
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==Overview==
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1-l-myo-Inositol-1-phosphate synthase catalyzes the conversion of d-glucose 6-phosphate to 1-l-myo-inositol-1-phosphate (MIP), the first and rate-limiting step in the biosynthesis of all inositol-containing compounds. It involves an oxidation, intramolecular aldol cyclization, and reduction. We have determined the first crystal structure of MIP synthase. We present structures of both the NAD-bound enzyme and the enzyme bound to an inhibitor, 2-deoxy-glucitol-6-phosphate. While 58 amino acids are disordered in the unbound form of the enzyme in the vicinity of the active site, the inhibitor nucleates the folding of this domain in a striking example of induced fit, serving to completely encapsulate it within the enzyme. Three helices and a long beta-strand are formed in this process. We postulate a mechanism for the conversion based on the structure of the inhibitor-bound complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_11779862}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11779862 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11779862}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor-bound structure]]
[[Category: Inhibitor-bound structure]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:19:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:23:03 2008''

Revision as of 17:23, 1 July 2008

Image:1jki.png

Template:STRUCTURE 1jki

myo-Inositol-1-phosphate Synthase Complexed with an Inhibitor, 2-deoxy-glucitol-6-phosphate

Template:ABSTRACT PUBMED 11779862

About this Structure

1JKI is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthase., Stein AJ, Geiger JH, J Biol Chem. 2002 Mar 15;277(11):9484-91. Epub 2002 Jan 4. PMID:11779862

Page seeded by OCA on Tue Jul 1 20:23:03 2008

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