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1jof

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{{STRUCTURE_1jof| PDB=1jof | SCENE= }}
{{STRUCTURE_1jof| PDB=1jof | SCENE= }}
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'''Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme'''
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===Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme===
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==Overview==
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Muconate lactonizing enzymes (MLEs) convert cis,cis-muconates to muconolactones in microbes as part of the beta-ketoadipate pathway; some also dehalogenate muconate derivatives of xenobiotic haloaromatics. There are three different MLE classes unrelated by evolution. We present the X-ray structure of a eukaryotic MLE, Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme (NcCMLE) at 2.5 A resolution, with a seven-bladed beta propeller fold. It is related neither to bacterial MLEs nor to other beta propeller enzymes, but is structurally similar to the G protein beta subunit. It reveals a novel metal-independent cycloisomerase motif unlike the bacterial metal cofactor MLEs. Together, the bacterial MLEs and NcCMLE structures comprise a striking structural example of functional convergence in enzymes for 1,2-addition-elimination of carboxylic acids. NcCMLE and bacterial MLEs may enhance the reaction rate differently: the former by electrophilic catalysis and the latter by electrostatic stabilization of the enolate.
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(as it appears on PubMed at http://www.pubmed.gov), where 11937053 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11937053}}
==About this Structure==
==About this Structure==
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[[Category: Homotetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:30:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:33:16 2008''

Revision as of 17:33, 1 July 2008

Image:1jof.png

Template:STRUCTURE 1jof

Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme

Template:ABSTRACT PUBMED 11937053

About this Structure

1JOF is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase., Kajander T, Merckel MC, Thompson A, Deacon AM, Mazur P, Kozarich JW, Goldman A, Structure. 2002 Apr;10(4):483-92. PMID:11937053

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