This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jpe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jpe.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1jpe.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jpe| PDB=1jpe | SCENE= }}
{{STRUCTURE_1jpe| PDB=1jpe | SCENE= }}
-
'''Crystal structure of DsbD-alpha; the N-terminal domain of DsbD'''
+
===Crystal structure of DsbD-alpha; the N-terminal domain of DsbD===
-
==Overview==
+
<!--
-
The Escherichia coli disulfide bond isomerase DsbC rearranges incorrect disulfide bonds during oxidative protein folding. It is specifically activated by the periplasmic N-terminal domain (DsbDalpha) of the transmembrane electron transporter DsbD. An intermediate of the electron transport reaction was trapped, yielding a covalent DsbC-DsbDalpha complex. The 2.3 A crystal structure of the complex shows for the first time the specific interactions between two thiol oxidoreductases. DsbDalpha is a novel thiol oxidoreductase with the active site cysteines embedded in an immunoglobulin fold. It binds into the central cleft of the V-shaped DsbC dimer, which assumes a closed conformation on complex formation. Comparison of the complex with oxidized DsbDalpha reveals major conformational changes in a cap structure that regulates the accessibility of the DsbDalpha active site. Our results explain how DsbC is selectively activated by DsbD using electrons derived from the cytoplasm.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12234918}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12234918 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12234918}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Inner membrane]]
[[Category: Inner membrane]]
[[Category: Redox-active center]]
[[Category: Redox-active center]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:32:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:35:41 2008''

Revision as of 17:35, 1 July 2008

Image:1jpe.png

Template:STRUCTURE 1jpe

Crystal structure of DsbD-alpha; the N-terminal domain of DsbD

Template:ABSTRACT PUBMED 12234918

About this Structure

1JPE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The disulfide bond isomerase DsbC is activated by an immunoglobulin-fold thiol oxidoreductase: crystal structure of the DsbC-DsbDalpha complex., Haebel PW, Goldstone D, Katzen F, Beckwith J, Metcalf P, EMBO J. 2002 Sep 16;21(18):4774-84. PMID:12234918

Page seeded by OCA on Tue Jul 1 20:35:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jpe"
Personal tools