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1jql

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[[Image:1jql.jpg|left|200px]]
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{{STRUCTURE_1jql| PDB=1jql | SCENE= }}
{{STRUCTURE_1jql| PDB=1jql | SCENE= }}
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'''Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of beta-delta (1-140)'''
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===Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of beta-delta (1-140)===
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==Overview==
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The dimeric ring-shaped sliding clamp of E. coli DNA polymerase III (beta subunit, homolog of eukaryotic PCNA) is loaded onto DNA by the clamp loader gamma complex (homolog of eukaryotic Replication Factor C, RFC). The delta subunit of the gamma complex binds to the beta ring and opens it. The crystal structure of a beta:delta complex shows that delta, which is structurally related to the delta' and gamma subunits of the gamma complex, is a molecular wrench that induces or traps a conformational change in beta such that one of its dimer interfaces is destabilized. Structural comparisons and molecular dynamics simulations suggest a spring-loaded mechanism in which the beta ring opens spontaneously once a dimer interface is perturbed by the delta wrench.
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The line below this paragraph, {{ABSTRACT_PUBMED_11525728}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11525728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11525728}}
==About this Structure==
==About this Structure==
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[[Category: Dna replication]]
[[Category: Dna replication]]
[[Category: Processivity clamp]]
[[Category: Processivity clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:39:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:38:59 2008''

Revision as of 17:39, 1 July 2008

Image:1jql.png

Template:STRUCTURE 1jql

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of beta-delta (1-140)

Template:ABSTRACT PUBMED 11525728

About this Structure

1JQL is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III., Jeruzalmi D, Yurieva O, Zhao Y, Young M, Stewart J, Hingorani M, O'Donnell M, Kuriyan J, Cell. 2001 Aug 24;106(4):417-28. PMID:11525728

Page seeded by OCA on Tue Jul 1 20:38:59 2008

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