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1jro

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{{STRUCTURE_1jro| PDB=1jro | SCENE= }}
{{STRUCTURE_1jro| PDB=1jro | SCENE= }}
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'''Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus'''
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===Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus===
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==Overview==
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Xanthine dehydrogenase (XDH), a complex molybdo/iron-sulfur/flavoprotein, catalyzes the oxidation of hypoxanthine to xanthine followed by oxidation of xanthine to uric acid with concomitant reduction of NAD+. The 2.7 A resolution structure of Rhodobacter capsulatus XDH reveals that the bacterial and bovine XDH have highly similar folds despite differences in subunit composition. The NAD+ binding pocket of the bacterial XDH resembles that of the dehydrogenase form of the bovine enzyme rather than that of the oxidase form, which reduces O(2) instead of NAD+. The drug allopurinol is used to treat XDH-catalyzed uric acid build-up occurring in gout or during cancer chemotherapy. As a hypoxanthine analog, it is oxidized to alloxanthine, which cannot be further oxidized but acts as a tight binding inhibitor of XDH. The 3.0 A resolution structure of the XDH-alloxanthine complex shows direct coordination of alloxanthine to the molybdenum via a nitrogen atom. These results provide a starting point for the rational design of new XDH inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 11796116 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11796116}}
==About this Structure==
==About this Structure==
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[[Category: Xdh]]
[[Category: Xdh]]
[[Category: Xo]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:46:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:42:06 2008''

Revision as of 17:42, 1 July 2008

Image:1jro.png

Template:STRUCTURE 1jro

Crystal Structure of Xanthine Dehydrogenase from Rhodobacter capsulatus

Template:ABSTRACT PUBMED 11796116

About this Structure

1JRO is a Protein complex structure of sequences from Rhodobacter capsulatus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus., Truglio JJ, Theis K, Leimkuhler S, Rappa R, Rajagopalan KV, Kisker C, Structure. 2002 Jan;10(1):115-25. PMID:11796116

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