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1jst

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[[Image:1jst.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1jst| PDB=1jst | SCENE= }}
{{STRUCTURE_1jst| PDB=1jst | SCENE= }}
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'''PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A'''
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===PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A===
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==Overview==
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Cyclin-dependent kinase (CDK)-cyclin complexes require phosphorylation on the CDK subunit for full activation of their Ser/Thr protein kinase activity. The crystal structure of the phosphorylated CDK2-CyclinA-ATP gamma S complex has been determined at 2.6 A resolution. The phosphate group, which is on the regulatory T-loop of CDK2, is mostly buried, its charge being neutralized by three Arg side chains. The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA. Comparison with the unphosphorylated CDK2-CyclinA complex shows that the T-loop moves by as much as 7 A, and this affects the putative substrate binding site as well as resulting in additional CDK2-CyclinA contacts. The phosphate group thus acts as a major organizing centre in the CDK2-CyclinA complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_8756328}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8756328 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8756328}}
==About this Structure==
==About this Structure==
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[[Category: Cyclin]]
[[Category: Cyclin]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 20:44:56 2008''

Revision as of 17:44, 1 July 2008

Image:1jst.png

Template:STRUCTURE 1jst

PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A

Template:ABSTRACT PUBMED 8756328

About this Structure

1JST is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of cyclin-dependent kinase activation by phosphorylation., Russo AA, Jeffrey PD, Pavletich NP, Nat Struct Biol. 1996 Aug;3(8):696-700. PMID:8756328

Page seeded by OCA on Tue Jul 1 20:44:56 2008

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