1k2a

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[[Image:1k2a.gif|left|200px]]
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{{STRUCTURE_1k2a| PDB=1k2a | SCENE= }}
{{STRUCTURE_1k2a| PDB=1k2a | SCENE= }}
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'''Modified Form of Eosinophil-derived Neurotoxin'''
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===Modified Form of Eosinophil-derived Neurotoxin===
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==Overview==
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The crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A). Two of the extra residues can be placed unambiguously, while the density corresponding to two others is poor. The modified N terminus appears to influence the position of the catalytically important His129, possibly explaining the diminished catalytic activity of this variant. However, (-4)EDN has been shown to be cytotoxic to a Kaposi's sarcoma tumor cell line and other endothelial cell lines. Analysis of the structure and function suggests that the reason for cytotoxicity is most likely due to cellular recognition by the N-terminal extension, since the intrinsic activity of the enzyme is not sufficient for cytotoxicity and the N-terminal extension does not affect the conformation of EDN.
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(as it appears on PubMed at http://www.pubmed.gov), where 11916383 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11916383}}
==About this Structure==
==About this Structure==
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:26:11 2008''

Revision as of 18:26, 1 July 2008

Image:1k2a.png

Template:STRUCTURE 1k2a

Modified Form of Eosinophil-derived Neurotoxin

Template:ABSTRACT PUBMED 11916383

About this Structure

1K2A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities., Chang C, Newton DL, Rybak SM, Wlodawer A, J Mol Biol. 2002 Mar 15;317(1):119-30. PMID:11916383

Page seeded by OCA on Tue Jul 1 21:26:11 2008

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