1k2d

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{{STRUCTURE_1k2d| PDB=1k2d | SCENE= }}
{{STRUCTURE_1k2d| PDB=1k2d | SCENE= }}
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'''Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A'''
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===Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A===
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==Overview==
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Murine experimental allergic encephalomyelitis (EAE) is a useful model for the demyelinating, autoimmune disease multiple sclerosis. In the EAE system, the immunodominant N-terminal epitope of myelin basic protein (MBP) is an unusually short, weakly binding peptide antigen which elicits highly biased TCR chain usage. In the 2.2 A crystal structure of I-A(u)/MBP1-11 complex, only MBP residues 1-7 are bound toward one end of the peptide binding cleft. The fourth residue of MBP1-11 is located in an incompatible p6 pocket of I-A(u), thus explaining the short half-life of I-A(u) complexed with Ac1-11. MBP peptides extended at the C terminus of Ac1-11 result in dramatic affinity increases, likely attributed to register shifting to a higher affinity cryptic epitope, which could potentially mask the presentation of the immunodominant MBP1-11 peptide during thymic education.
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(as it appears on PubMed at http://www.pubmed.gov), where 12150894 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12150894}}
==About this Structure==
==About this Structure==
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[[Category: Myelin basic protein]]
[[Category: Myelin basic protein]]
[[Category: Unique register]]
[[Category: Unique register]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 21:27:52 2008''

Revision as of 18:28, 1 July 2008

Image:1k2d.png

Template:STRUCTURE 1k2d

Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A

Template:ABSTRACT PUBMED 12150894

About this Structure

1K2D is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au., He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC, Immunity. 2002 Jul;17(1):83-94. PMID:12150894

Page seeded by OCA on Tue Jul 1 21:27:52 2008

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