This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k4u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1k4u.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1k4u.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1k4u| PDB=1k4u | SCENE= }}
{{STRUCTURE_1k4u| PDB=1k4u | SCENE= }}
-
'''Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox'''
+
===Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox===
-
==Overview==
+
<!--
-
The basic function of the Src homology 3 (SH3) domain is considered to be binding to proline-rich sequences containing a PxxP motif. Recently, many SH3 domains, including those from Grb2 and Pex13p, were reported to bind sequences lacking a PxxP motif. We report here that the 22 residue peptide lacking a PxxP motif, derived from p47(phox), binds to the C-terminal SH3 domain from p67(phox). We applied the NMR cross-saturation method to locate the interaction sites for the non-PxxP peptides on their cognate SH3 domains from p67(phox), Grb2 and Pex13p. The binding site of the Grb2 SH3 partially overlapped the conventional PxxP-binding site, whereas those of p67(phox) and Pex13p SH3s are located in different surface regions. The non-PxxP peptide from p47(phox) binds to the p67(phox) SH3 more tightly when it extends to the N-terminus to include a typical PxxP motif, which enabled the structure determination of the complex, to reveal that the non-PxxP peptide segment interacted with the p67(phox) SH3 in a compact helix-turn-helix structure (PDB entry 1K4U).
+
The line below this paragraph, {{ABSTRACT_PUBMED_12169629}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12169629 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12169629}}
==Disease==
==Disease==
Line 19: Line 23:
==About this Structure==
==About this Structure==
-
1K4U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4U OCA].
+
1K4U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4U OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: P67phox]]
[[Category: P67phox]]
[[Category: Sh3-peptide complex]]
[[Category: Sh3-peptide complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:18:33 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:46:42 2008''

Revision as of 06:46, 2 July 2008

Image:1k4u.png

Template:STRUCTURE 1k4u

Contents

Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox

Template:ABSTRACT PUBMED 12169629

Disease

Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-2 OMIM:[608515], Chronic granulomatous disease due to deficiency of NCF-1 OMIM:[608512]

About this Structure

1K4U is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p., Kami K, Takeya R, Sumimoto H, Kohda D, EMBO J. 2002 Aug 15;21(16):4268-76. PMID:12169629

Page seeded by OCA on Wed Jul 2 09:46:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k4u"
Personal tools