1k6f

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{{STRUCTURE_1k6f| PDB=1k6f | SCENE= }}
{{STRUCTURE_1k6f| PDB=1k6f | SCENE= }}
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'''Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3'''
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===Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3===
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==Overview==
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The first report of the full-length structure of the collagen-like polypeptide [(Pro-Pro-Gly)(10)](3) is given. This structure was obtained from crystals grown in a microgravity environment, which diffracted up to 1.3 A, using synchrotron radiation. The final model, which was refined to an R(factor) of 0.18, is the highest-resolution description of a collagen triple helix reported to date. This structure provides clues regarding a series of aspects related to collagen triple helix structure and assembly. The strict dependence of proline puckering on the position inside the Pro-Pro-Gly triplets and the correlation between backbone and side chain dihedral angles support the propensity-based mechanism of triple helix stabilization/destabilization induced by hydroxyproline. Furthermore, the analysis of [(Pro-Pro-Gly)(10)](3) packing, which is governed by electrostatic interactions, suggests that charges may act as locking features in the axial organization of triple helices in the collagen fibrils.
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(as it appears on PubMed at http://www.pubmed.gov), where 11790836 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11790836}}
==About this Structure==
==About this Structure==
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[[Category: Puckering]]
[[Category: Puckering]]
[[Category: Triple helix]]
[[Category: Triple helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 09:51:15 2008''

Revision as of 06:51, 2 July 2008

Template:STRUCTURE 1k6f

Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3

Template:ABSTRACT PUBMED 11790836

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)(10)](3)., Berisio R, Vitagliano L, Mazzarella L, Zagari A, Protein Sci. 2002 Feb;11(2):262-70. PMID:11790836

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