1k78

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{{STRUCTURE_1k78| PDB=1k78 | SCENE= }}
{{STRUCTURE_1k78| PDB=1k78 | SCENE= }}
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'''Pax5(1-149)+Ets-1(331-440)+DNA'''
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===Pax5(1-149)+Ets-1(331-440)+DNA===
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==Overview==
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Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
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(as it appears on PubMed at http://www.pubmed.gov), where 11779502 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11779502}}
==Disease==
==Disease==
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[[Category: Paired domain]]
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[[Category: Transcription factor]]
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Revision as of 06:53, 2 July 2008

Image:1k78.png

Template:STRUCTURE 1k78

Contents

Pax5(1-149)+Ets-1(331-440)+DNA

Template:ABSTRACT PUBMED 11779502

Disease

Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]

About this Structure

1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502

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