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1ka1

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[[Image:1ka1.gif|left|200px]]
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{{STRUCTURE_1ka1| PDB=1ka1 | SCENE= }}
{{STRUCTURE_1ka1| PDB=1ka1 | SCENE= }}
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'''The PAPase Hal2p complexed with calcium and magnesium ions and reaction substrate: PAP'''
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===The PAPase Hal2p complexed with calcium and magnesium ions and reaction substrate: PAP===
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==Overview==
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Li(+)-sensitive/Mg(2+)-dependent phosphatases have attracted considerable attention since they have been proposed as targets for lithium therapy in the treatment of manic-depressive patients. The members of this enzyme superfamily display low levels of sequence identity while possessing a common fold and active site. Extensive structural and biochemical data demonstrate the direct involvement of two metal ions in catalysis, and show that lithium exerts its inhibitory action by blocking the products at the active site. By exploiting the different inhibitory properties of magnesium and calcium, we have been able to solve the X-ray structures of the Li(+)-sensitive/Mg(2+)-dependent 3'-phosphoadenosine-5'-phosphatase in complex with its substrate and with its products. The structural comparison of these complexes provides a 3D picture of the different stages of the catalytic cycle. This gives new insights into the understanding of the biological function of this group of enzymes and their lithium inhibition, and should assist in the design of improved inhibitors of therapeutic value.
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(as it appears on PubMed at http://www.pubmed.gov), where 12126627 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12126627}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotidase]]
[[Category: Nucleotidase]]
[[Category: Salt tolerance]]
[[Category: Salt tolerance]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:29:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:00:59 2008''

Revision as of 07:01, 2 July 2008

Image:1ka1.png

Template:STRUCTURE 1ka1

The PAPase Hal2p complexed with calcium and magnesium ions and reaction substrate: PAP

Template:ABSTRACT PUBMED 12126627

About this Structure

1KA1 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases., Patel S, Martinez-Ripoll M, Blundell TL, Albert A, J Mol Biol. 2002 Jul 26;320(5):1087-94. PMID:12126627

Page seeded by OCA on Wed Jul 2 10:00:59 2008

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