1kem

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[[Image:1kem.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1kem| PDB=1kem | SCENE= }}
{{STRUCTURE_1kem| PDB=1kem | SCENE= }}
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'''CATALYTIC ANTIBODY 28B4 FAB FRAGMENT'''
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===CATALYTIC ANTIBODY 28B4 FAB FRAGMENT===
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==Overview==
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The x-ray crystal structures of the sulfide oxidase antibody 28B4 and of antibody 28B4 complexed with hapten have been solved at 2.2-angstrom and 1.9-angstrom resolution, respectively. To our knowledge, these structures are the highest resolution catalytic antibody structures to date and provide insight into the molecular mechanism of this antibody-catalyzed monooxygenation reaction. Specifically, the data suggest that entropic restriction plays a fundamental role in catalysis through the precise alignment of the thioether substrate and oxidant. The antibody active site also stabilizes developing charge on both sulfur and periodate in the transition state via cation-pi and electrostatic interactions, respectively. In addition to demonstrating that the active site of antibody 28B4 does indeed reflect the mechanistic information programmed in the aminophosphonic acid hapten, these high-resolution structures provide a basis for enhancing turnover rates through mutagenesis and improved hapten design.
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(as it appears on PubMed at http://www.pubmed.gov), where 8643580 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8643580}}
==About this Structure==
==About this Structure==
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[[Category: Oxygenation]]
[[Category: Oxygenation]]
[[Category: Sulfide oxidation]]
[[Category: Sulfide oxidation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:38:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:13:28 2008''

Revision as of 07:13, 2 July 2008

Image:1kem.png

Template:STRUCTURE 1kem

CATALYTIC ANTIBODY 28B4 FAB FRAGMENT

Template:ABSTRACT PUBMED 8643580

About this Structure

1KEM is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution., Hsieh-Wilson LC, Schultz PG, Stevens RC, Proc Natl Acad Sci U S A. 1996 May 28;93(11):5363-7. PMID:8643580

Page seeded by OCA on Wed Jul 2 10:13:28 2008

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