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1kgc

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[[Image:1kgc.gif|left|200px]]
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[[Image:1kgc.png|left|200px]]
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{{STRUCTURE_1kgc| PDB=1kgc | SCENE= }}
{{STRUCTURE_1kgc| PDB=1kgc | SCENE= }}
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'''Immune Receptor'''
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===Immune Receptor===
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==Overview==
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Despite a potential repertoire of &gt;10(15) alphabeta T cell receptors (TcR), the HLA B8-restricted cytolytic T cell response to a latent antigen of Epstein-Barr virus (EBV) is strikingly limited in the TcR sequences that are selected. Even in unrelated individuals this response is dominated by a single highly restricted TcR clonotype that selects identical combinations of hypervariable Valpha, Vbeta, D, J, and N region genes. We have determined the 1.5 A crystal structure of this "public" TcR, revealing that five of the six hypervariable loops adopt novel conformations providing a unique combining site that contains a deep pocket predicted to overlay the HLA B8-peptide complex. The findings suggest a structural basis for the immunodominance of this clonotype in the immune response to EBV.
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(as it appears on PubMed at http://www.pubmed.gov), where 12429093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12429093}}
==About this Structure==
==About this Structure==
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[[Category: Lc13 clone]]
[[Category: Lc13 clone]]
[[Category: T-cell receptor]]
[[Category: T-cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:42:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:18:14 2008''

Revision as of 07:18, 2 July 2008

Image:1kgc.png

Template:STRUCTURE 1kgc

Immune Receptor

Template:ABSTRACT PUBMED 12429093

About this Structure

1KGC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance., Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J, Structure. 2002 Nov;10(11):1521-32. PMID:12429093

Page seeded by OCA on Wed Jul 2 10:18:14 2008

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