1kj2

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[[Image:1kj2.gif|left|200px]]
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{{Seed}}
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[[Image:1kj2.png|left|200px]]
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{{STRUCTURE_1kj2| PDB=1kj2 | SCENE= }}
{{STRUCTURE_1kj2| PDB=1kj2 | SCENE= }}
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'''Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex'''
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===Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex===
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==Overview==
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The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR and an octapeptide bound to the allogeneic H-2K(b) MHC class I molecule. This structure reveals how a tremendously large CDR3beta conformational change allows the KB5-C20 TCR to adapt to the rather constrained pMHC surface and achieve a diagonal docking mode. This extreme case of induced fit also shows that TCR plasticity is primarily restricted to CDR3 loops and does not propagate away from the antigen binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_11911820}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11911820 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11911820}}
==About this Structure==
==About this Structure==
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[[Category: T cell receptor]]
[[Category: T cell receptor]]
[[Category: Tcr-pmhc complex]]
[[Category: Tcr-pmhc complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:48:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:25:08 2008''

Revision as of 07:25, 2 July 2008

Image:1kj2.png

Template:STRUCTURE 1kj2

Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex

Template:ABSTRACT PUBMED 11911820

About this Structure

1KJ2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex., Reiser JB, Gregoire C, Darnault C, Mosser T, Guimezanes A, Schmitt-Verhulst AM, Fontecilla-Camps JC, Mazza G, Malissen B, Housset D, Immunity. 2002 Mar;16(3):345-54. PMID:11911820

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