1kjs

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[[Image:1kjs.jpg|left|200px]]
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{{STRUCTURE_1kjs| PDB=1kjs | SCENE= }}
{{STRUCTURE_1kjs| PDB=1kjs | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES'''
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===NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES===
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==Overview==
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The serum glycoprotein C5a, which is derived from the proteolytic cleavage of complement protein C5, has been implicated in the pathogenesis of a number of inflammatory and allergic conditions. Because C5a induces an inflammatory response upon binding to a specific receptor, structural and mutagenesis studies were carried out to gain a better understanding of this binding interaction. These studies led to the first structural definition of the C terminus of recombinant human (rh)-C5a, determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. Our results show that the C terminus adopts an alpha-helical conformation spanning residues 69 to 74, while the core domain exists as an antiparallel alpha-helical bundle. This C-terminal helix is connected to the core by a short loop that orients Arg 74 adjacent to Arg 62. Point mutation analysis had already revealed that residues 62 and 74 significantly contribute to agonist activity and receptor binding. Correlation of the C5a tertiary structure with mutational analyses clarifies the significance of the functional and binding properties of Arg 62 and suggests that both Arg 62 and Arg 74 interact at the same binding site on the receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 9188742 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9188742}}
==About this Structure==
==About this Structure==
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1KJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJS OCA].
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1KJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJS OCA].
==Reference==
==Reference==
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[[Category: Chemotaxis]]
[[Category: Chemotaxis]]
[[Category: Gp agonist]]
[[Category: Gp agonist]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:49:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:26:41 2008''

Revision as of 07:26, 2 July 2008

Image:1kjs.png

Template:STRUCTURE 1kjs

NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES

Template:ABSTRACT PUBMED 9188742

About this Structure

1KJS is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy., Zhang X, Boyar W, Toth MJ, Wennogle L, Gonnella NC, Proteins. 1997 Jun;28(2):261-7. PMID:9188742

Page seeded by OCA on Wed Jul 2 10:26:41 2008

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