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1kmh

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[[Image:1kmh.gif|left|200px]]
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{{Seed}}
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[[Image:1kmh.png|left|200px]]
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{{STRUCTURE_1kmh| PDB=1kmh | SCENE= }}
{{STRUCTURE_1kmh| PDB=1kmh | SCENE= }}
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'''Crystal Structure of spinach chloroplast F1-ATPase complexed with tentoxin'''
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===Crystal Structure of spinach chloroplast F1-ATPase complexed with tentoxin===
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==Overview==
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Tentoxin, a natural cyclic tetrapeptide produced by phytopathogenic fungi from the Alternaria species affects the catalytic function of the chloroplast F(1)-ATPase in certain sensitive species of plants. In this study, we show that the uncompetitive inhibitor tentoxin binds to the alphabeta-interface of the chloroplast F(1)-ATPase in a cleft localized at betaAsp-83. Most of the binding site is located on the noncatalytic alpha-subunit. The crystal structure of the tentoxin-inhibited CF(1)-complex suggests that the inhibitor is hydrogen bonded to Asp-83 in the catalytic beta-subunit but forms hydrophobic contacts with residues Ile-63, Leu-65, Val-75, Tyr-237, Leu-238, and Met-274 in the adjacent alpha-subunit. Except for minor changes around the tentoxin-binding site, the structure of the chloroplast alpha(3)beta(3)-core complex is the same as that determined with the native chloroplast ATPase. Tentoxin seems to act by inhibiting inter-subunit contacts at the alphabeta-interface and by blocking the interconversion of binding sites in the catalytic mechanism.
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The line below this paragraph, {{ABSTRACT_PUBMED_11904410}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11904410 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11904410}}
==About this Structure==
==About this Structure==
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[[Category: Groth, G.]]
[[Category: Groth, G.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:54:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:33:21 2008''

Revision as of 07:33, 2 July 2008

Image:1kmh.png

Template:STRUCTURE 1kmh

Crystal Structure of spinach chloroplast F1-ATPase complexed with tentoxin

Template:ABSTRACT PUBMED 11904410

About this Structure

1KMH is a Protein complex structure of sequences from Spinacia oleracea. Full crystallographic information is available from OCA.

Reference

Structure of spinach chloroplast F1-ATPase complexed with the phytopathogenic inhibitor tentoxin., Groth G, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3464-8. PMID:11904410

Page seeded by OCA on Wed Jul 2 10:33:21 2008

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