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1kn7

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[[Image:1kn7.gif|left|200px]]
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{{STRUCTURE_1kn7| PDB=1kn7 | SCENE= }}
{{STRUCTURE_1kn7| PDB=1kn7 | SCENE= }}
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'''Solution structure of the tandem inactivation domain (residues 1-75) of potassium channel RCK4 (Kv1.4)'''
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===Solution structure of the tandem inactivation domain (residues 1-75) of potassium channel RCK4 (Kv1.4)===
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==Overview==
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Cumulative inactivation of voltage-gated (Kv) K(+) channels shapes the presynaptic action potential and determines timing and strength of synaptic transmission. Kv1.4 channels exhibit rapid "ball-and-chain"-type inactivation gating. Different from all other Kvalpha subunits, Kv1.4 harbors two inactivation domains at its N terminus. Here we report the solution structure and function of this "tandem inactivation domain" using NMR spectroscopy and patch clamp recordings. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N terminus anchored at a 5-turn helix, whereas ID2 (residues 40-50) is a 2.5-turn helix made up of small hydrophobic amino acids. Functional analysis suggests that only ID1 may work as a pore-occluding ball domain, whereas ID2 most likely acts as a "docking domain" that attaches ID1 to the cytoplasmic face of the channel. Deletion of ID2 slows inactivation considerably and largely impairs cumulative inactivation. Together, the concerted action of ID1 and ID2 may promote rapid inactivation of Kv1.4 that is crucial for the channel function in short term plasticity.
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{{ABSTRACT_PUBMED_12590144}}
==About this Structure==
==About this Structure==
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1KN7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN7 OCA].
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1KN7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN7 OCA].
==Reference==
==Reference==
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[[Category: Rck4]]
[[Category: Rck4]]
[[Category: Voltage-gated potassium channel]]
[[Category: Voltage-gated potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:35:16 2008''

Revision as of 07:35, 2 July 2008

Image:1kn7.png

Template:STRUCTURE 1kn7

Solution structure of the tandem inactivation domain (residues 1-75) of potassium channel RCK4 (Kv1.4)

Template:ABSTRACT PUBMED 12590144

About this Structure

1KN7 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4., Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer HR, Bentrop D, Fakler B, J Biol Chem. 2003 May 2;278(18):16142-50. Epub 2003 Feb 16. PMID:12590144

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